Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15677
R64736		 Oberlander (Controls unexposed, disease free) (Indications other than epilepsy), 2004 Poor neonatal adaptation (high level of medical care and observation) during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Co-administration Indication BZD: Psychiatric diseases (depression, anxiety, ...) 6.68 [1.18;37.79] C
excluded (control group) 		7/18   2/23 9 18
ref
S15678
R64742		 Oberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 Poor neonatal adaptation (high level of medical care and observation) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Co-administration Indication BZD: Psychiatric diseases (depression, anxiety, ...) 1.91 [0.53;6.84] C 7/18   7/28 14 18
ref
Total 1 studies 1.91 [0.53;6.84] 14 18
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Oberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004Oberlander, 2004 1 1.91[0.53; 6.84]14180%ROB confusion: criticalROB selection: lowROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick) (Indications other than epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 Tags Adjustment   - No  - No 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 Co-administrationCo-administration 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 All studiesAll studies 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15677

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.68[1.18; 37.79]918 -NAOberlander (Controls unexposed, disease free) (Indications other than epilepsy), 2004 1 unexposed, sick controlsunexposed, sick controls 1.91[0.53; 6.84]1418 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 10.510.01.0