Tricyclic antidepressants updated on 07-01-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10937
R40707		 Ban (Controls exposed to SSRIs), 2014 Chromosomal malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 1.27 [0.40;4.04] C
excluded (control group) 		4/2,428   10/7,683 14 2,428
ref
S10938
R40723		 Ban (Controls unexposed, disease free), 2014 Chromosomal malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: Yes Monotherapy: TCA only 0.90 [0.34;2.43]
excluded (control group) 		4/2,428   551/325,294 555 2,428
ref
S10939
R40745		 Ban (Controls unexposed, sick), 2014 Chromosomal malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 0.82 [0.29;2.34] C 4/2,428   27/13,432 31 2,428
ref
S10930
R40613		 Davis, 2007 Chromosomal anomalies 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.61 [0.10;26.03] C 0/167   92/49,669 92 167
ref
Total 2 studies 0.89 [0.33;2.38] 123 2,595
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Controls unexposed, sick), 2014Ban, 2014 1 0.82[0.29; 2.34]312,42888%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 1.61[0.10; 26.03]9216712%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.89[0.33; 2.38]1232,5950.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.33; 2.38]1232,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.61[0.10; 26.03]92167 -NADavis, 2007 1 unexposed, sickunexposed, sick 0.82[0.29; 2.34]312,428 -NABan (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 0.89[0.33; 2.38]1232,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 2 Monotherapy   - no or not specified  - no or not specified 1.61[0.10; 26.03]92167 -NADavis, 2007 1   - TCA only  - TCA only 0.82[0.29; 2.34]312,428 -NABan (Controls unexposed, sick), 2014 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 0.82[0.29; 2.34]312,428 -NABan (Controls unexposed, sick), 2014 1 All studiesAll studies 0.89[0.33; 2.38]1232,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10937, 10938

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.38; 2.43]6472,5950%NABan (Controls unexposed, disease free), 2014 Davis, 2007 2 unexposed, sick controlsunexposed, sick controls 0.82[0.29; 2.34]312,428 -NABan (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.27[0.40; 4.04]142,428 -NABan (Controls exposed to SSRIs), 2014 10.510.01.0