Tricyclic antidepressants updated on 07-01-2025

Abdominal wall defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10937
R40716		 Ban (Controls exposed to SSRIs), 2014 Abdominal wall malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 0.45 [0.02;8.75] C
excluded (control group) 		0/2,428   3/7,683 3 2,428
ref
S10938
R40732		 Ban (Controls unexposed, disease free), 2014 Abdominal wall malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No Monotherapy: TCA only 0.96 [0.06;15.57] C
excluded (control group) 		0/2,428   69/325,294 69 2,428
ref
S10939
R40754		 Ban (Controls unexposed, sick), 2014 Abdominal wall malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.11 [0.05;23.05] C 0/2,428   2/13,432 2 2,428
ref
Total 1 studies 1.11 [0.05;23.05] 2 2,428
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Controls unexposed, sick), 2014Ban, 2014 1 1.11[0.05; 23.05]22,4280%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 1 Monotherapy   - TCA only  - TCA only 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 1 All studiesAll studies 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10937, 10938

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.06; 15.57]692,428 -NABan (Controls unexposed, disease free), 2014 1 unexposed, sick controlsunexposed, sick controls 1.11[0.05; 23.05]22,428 -NABan (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.45[0.02; 8.75]32,428 -NABan (Controls exposed to SSRIs), 2014 10.510.01.0