Tricyclic antidepressants updated on 07-01-2025

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11052
R40983		 Bérard (Controls unexposed, sick), 2017 Digestive system malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 2.55 [1.40;4.66] -/382   -/14,847 - 382
ref
S10937
R40711		 Ban (Controls exposed to SSRIs), 2014 Digestive system malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 0.86 [0.24;3.10] C
excluded (control group) 		3/2,428   11/7,683 14 2,428
ref
S10938
R40727		 Ban (Controls unexposed, disease free), 2014 Digestive system malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: Yes Monotherapy: TCA only 1.26 [0.40;3.94]
excluded (control group) 		3/2,428   313/325,294 316 2,428
ref
S10939
R40749		 Ban (Controls unexposed, sick), 2014 Digestive system malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.51 [0.42;5.41] C 3/2,428   11/13,432 14 2,428
ref
S10930
R40606		 Davis, 2007 Other congenital anomalies of digestive system 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.49 [0.35;17.50] 1/167   138/49,669 139 167
ref
Total 3 studies 2.33 [1.38;3.94] 153 2,977
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard (Controls unexposed, sick), 2017Bérard, 2017 1 2.55[1.40; 4.66]-38276%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Ban (Controls unexposed, sick), 2014Ban, 2014 2 1.51[0.42; 5.41]142,42817%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 2.49[0.35; 17.50]1391677%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 2.33[1.38; 3.94]1532,9770.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.33[1.38; 3.94]1532,9770%NABérard (Controls unexposed, sick), 2017 Ban (Controls unexposed, sick), 2014 Davis, 2007 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.49[0.35; 17.61]139167 -NADavis, 2007 1 unexposed, sickunexposed, sick 2.32[1.35; 3.99]142,8100%NABérard (Controls unexposed, sick), 2017 Ban (Controls unexposed, sick), 2014 2 Tags Adjustment   - No  - No 1.75[0.60; 5.11]1532,5950%NABan (Controls unexposed, sick), 2014 Davis, 2007 2   - Yes  - Yes 2.55[1.40; 4.65]-382 -NABérard (Controls unexposed, sick), 2017 1 Monotherapy   - no or not specified  - no or not specified 2.49[0.35; 17.61]139167 -NADavis, 2007 1   - TCA only  - TCA only 2.32[1.35; 3.99]142,8100%NABérard (Controls unexposed, sick), 2017 Ban (Controls unexposed, sick), 2014 2 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 2.32[1.35; 3.99]142,8100%NABérard (Controls unexposed, sick), 2017 Ban (Controls unexposed, sick), 2014 2 All studiesAll studies 2.33[1.38; 3.94]1532,9770%NABérard (Controls unexposed, sick), 2017 Ban (Controls unexposed, sick), 2014 Davis, 2007 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10937, 10938

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.50[0.56; 4.02]4552,5950%NABan (Controls unexposed, disease free), 2014 Davis, 2007 2 unexposed, sick controlsunexposed, sick controls 2.32[1.35; 3.99]142,8100%NABérard (Controls unexposed, sick), 2017 Ban (Controls unexposed, sick), 2014 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.86[0.24; 3.10]142,428 -NABan (Controls exposed to SSRIs), 2014 10.510.01.0