Tricyclic antidepressants updated on 07-01-2025

Eye defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10937
R40712		 Ban (Controls exposed to SSRIs), 2014 Eye malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 2.11 [0.60;7.49] C
excluded (control group) 		4/2,428   6/7,683 10 2,428
ref
S10938
R40728		 Ban (Controls unexposed, disease free), 2014 Eye malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: Yes Monotherapy: TCA only 1.68 [0.63;4.50]
excluded (control group) 		4/2,428   313/325,294 317 2,428
ref
S10939
R40750		 Ban (Controls unexposed, sick), 2014 Eye malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Monotherapy: TCA only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 2.46 [0.76;8.00] C 4/2,428   9/13,432 13 2,428
ref
S10930
R40598		 Davis, 2007 Congenital anomalies of eye 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.23 [0.01;3.64] C 0/167   649/49,669 649 167
ref
Total 2 studies 1.05 [0.11;9.88] 662 2,595
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Controls unexposed, sick), 2014Ban, 2014 1 2.46[0.76; 8.00]132,42864%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Davis, 2007Davis, 2007 0.23[0.01; 3.64]64916736%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 58% 1.05[0.11; 9.88]6622,5950.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.11; 9.88]6622,59558%NABan (Controls unexposed, sick), 2014 Davis, 2007 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.23[0.01; 3.64]649167 -NADavis, 2007 1 unexposed, sickunexposed, sick 2.46[0.76; 8.00]132,428 -NABan (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 1.05[0.11; 9.88]6622,59558%NABan (Controls unexposed, sick), 2014 Davis, 2007 2 Monotherapy   - no or not specified  - no or not specified 0.23[0.01; 3.64]649167 -NADavis, 2007 1   - TCA only  - TCA only 2.46[0.76; 8.00]132,428 -NABan (Controls unexposed, sick), 2014 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 2.46[0.76; 8.00]132,428 -NABan (Controls unexposed, sick), 2014 1 All studiesAll studies 1.05[0.11; 9.88]6622,59558%NABan (Controls unexposed, sick), 2014 Davis, 2007 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10937, 10938

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.16; 5.59]9662,59544%NABan (Controls unexposed, disease free), 2014 Davis, 2007 2 unexposed, sick controlsunexposed, sick controls 2.46[0.76; 8.00]132,428 -NABan (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.11[0.60; 7.49]102,428 -NABan (Controls exposed to SSRIs), 2014 10.510.01.0