Tricyclic antidepressants updated on 07-01-2025

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10935
R40675		 Simon (Controls exposed to SSRIs), 2002 Minor malformations during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 0.67 [0.32;1.38] C
excluded (control group) 		14/209   18/185 32 209
ref
S10936
R40691		 Simon (Controls unexposed, NOS), 2002 Minor malformations during pregnancy (anytime or not specified) excluded retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Matched Monotherapy: TCA only 0.76 [0.37;1.58]
excluded (exposition period) 		14/209   18/209 32 209
ref
S15445
R63526		 Kullander - Imipramine, 1976 Minor malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: No 3.04 [0.82;11.25] C 3/12   548/5,541 551 12
ref
Total 1 studies 3.04 [0.82;11.25] 551 12
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kullander - Imipramine, 1976Kullander - Imipramine, 1976 3.04[0.82; 11.25]551120%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.04[0.82; 11.25]55112 -NAKullander - Imipramine, 1976 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.04[0.82; 11.25]55112 -NAKullander - Imipramine, 1976 1 Tags Adjustment   - No  - No 3.04[0.82; 11.25]55112 -NAKullander - Imipramine, 1976 1 All studiesAll studies 3.04[0.82; 11.25]55112 -NAKullander - Imipramine, 1976 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10935

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.04[0.82; 11.25]55112 -NAKullander - Imipramine, 1976 10.510.01.0