Tricyclic antidepressants updated on 07-01-2025

Cognitive developmental disorders/delay (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10954
R53834		 Nulman (Controls unexposed, disease free), 2002 Mental development IQ with Bayley Scales of Infant Development-II at 15 and 30 months of age throughout pregnancy prospective cohort unexposed, disease free Adjustment: No extrapolated (cont. endpoint) Monotherapy: TCA only 0.48 [0.16;1.42] -/28   -/18 - 28
ref
S10953
R53835		 Nulman - Fluoxetine (Controls exposed to Fluoxetine), 2002 Mental development IQ with Bayley Scales of Infant Development-II at 15 and 30 months of age throughout pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No extrapolated (cont. endpoint) Monotherapy: TCA only 0.50 [0.20;1.25]
excluded (control group) 		-/28   -/33 - 28
ref
Total 1 studies 0.48 [0.16;1.43] 0 28
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nulman (Controls unexposed, disease free), 2002Nulman, 2002 1 0.48[0.16; 1.42]-280%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: lowROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 1 Tags Adjustment   - No  - No 0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 1 Monotherapy   - TCA only  - TCA only 0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 1 All studiesAll studies 0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10953

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.48[0.16; 1.43]-28 -NANulman (Controls unexposed, disease free), 2002 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.50[0.20; 1.25]-28 -NANulman - Fluoxetine (Controls exposed to Fluoxetine), 2002 10.510.01.0