Tricyclic antidepressants updated on 07-01-2025

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18247
R76562		 Suarez (Controls unexposed, discontinuers), 2022 Specific learning disorders - ≥ 1 ICD-9 Dx 315.0x, 315.1, 315.2 - At ≥ 2 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.82 [0.39;1.72] 13/3,494   21/4,258 34 3,494
ref
S18248
R76570		 Suarez (Controls unexposed, general pop), 2022 Specific learning disorders - ≥ 1 ICD-9 Dx 315.0x, 315.1, 315.2 - At ≥ 2 years of age 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.03 [0.59;1.81]
excluded (control group) 		13/3,511   4,797/1,789,773 4,810 3,511
ref
Total 1 studies 0.82 [0.39;1.72] 34 3,494
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Suarez (Controls unexposed, discontinuers), 2022Suarez, 2022 1 0.82[0.39; 1.72]343,4940%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, discontinuers;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 1 Tags Adjustment   - Yes  - Yes 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 1 Monotherapy   - no or not specified  - no or not specified 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 1 All studiesAll studies 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18248

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.03[0.59; 1.80]4,8103,511 -NASuarez (Controls unexposed, general pop), 2022 1 unexposed, sick controlsunexposed, sick controls 0.82[0.39; 1.72]343,494 -NASuarez (Controls unexposed, discontinuers), 2022 10.510.01.0