Tricyclic antidepressants updated on 07-01-2025

Neonatal hypoglycemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10933
R41684		 Reis (Controls exposed to SSRIs), 2010 Hypoglycaemia 2nd and/or 3rd trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 1.34 [0.98;1.83] C
excluded (control group) 		50/784   233/4,809 283 784
ref
S10934
R41678		 Reis (Controls unexposed, NOS), 2010 Neonatal hypoglycaemia 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: TCA only 1.83 [1.38;2.44] 50/784   34,794/1,062,190 34,844 784
ref
Total 1 studies 1.83 [1.38;2.43] 34,844 784
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reis (Controls unexposed, NOS), 2010Reis, 2010 1 1.83[1.38; 2.44]34,8447840%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.83[1.38; 2.43]34,844784 -NAReis (Controls unexposed, NOS), 2010 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.83[1.38; 2.43]34,844784 -NAReis (Controls unexposed, NOS), 2010 1 Tags Adjustment   - Yes  - Yes 1.83[1.38; 2.43]34,844784 -NAReis (Controls unexposed, NOS), 2010 1 Monotherapy   - TCA only  - TCA only 1.83[1.38; 2.43]34,844784 -NAReis (Controls unexposed, NOS), 2010 1 All studiesAll studies 1.83[1.38; 2.43]34,844784 -NAReis (Controls unexposed, NOS), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10933

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.83[1.38; 2.43]34,844784 -NAReis (Controls unexposed, NOS), 2010 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.34[0.98; 1.83]283784 -NAReis (Controls exposed to SSRIs), 2010 10.510.01.0