Tricyclic antidepressants updated on 07-01-2025

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10956
R40810		 Sørensen (Controls exposed to SSRIs), 2013 Childhood autism (ICD-10, codes ?) - At 4-14 years (mean 8.8 years) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: TCA only 0.69 [0.16;2.87] C
excluded (control group) 		2/642   34/7,506 36 642
ref
S10957
R40811		 Sørensen (Controls unexposed, NOS), 2013 Childhood autism (ICD-10, codes ?) - At 4-14 years (mean 8.8 years) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: TCA only 0.99 [0.25;3.98] C 2/642   2,030/646,782 2,032 642
ref
Total 1 studies 0.99 [0.25;3.98] 2,032 642
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Sørensen (Controls unexposed, NOS), 2013Sørensen, 2013 1 0.99[0.25; 3.98]2,0326420%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.99[0.25; 3.98]2,032642 -NASørensen (Controls unexposed, NOS), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.99[0.25; 3.98]2,032642 -NASørensen (Controls unexposed, NOS), 2013 1 Tags Adjustment   - No  - No 0.99[0.25; 3.98]2,032642 -NASørensen (Controls unexposed, NOS), 2013 1 Monotherapy   - TCA only  - TCA only 0.99[0.25; 3.98]2,032642 -NASørensen (Controls unexposed, NOS), 2013 1 All studiesAll studies 0.99[0.25; 3.98]2,032642 -NASørensen (Controls unexposed, NOS), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10956

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.99[0.25; 3.98]2,032642 -NASørensen (Controls unexposed, NOS), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.69[0.16; 2.87]36642 -NASørensen (Controls exposed to SSRIs), 2013 10.510.01.0