Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15322
R63047		 Ornoy - BZDs, 1998 Induced and spontaneous abortion at least 1st trimester prospective cohort unexposed, disease free Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 2.72 [1.85;4.00] C 106/460   42/424 148 460
ref
Total 1 studies 2.72 [1.85;4.00] 148 460
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ornoy - BZDs, 1998Ornoy - BZDs, 1998 2.72[1.85; 4.00]1484600%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.72[1.85; 4.00]148460 -NAOrnoy - BZDs, 1998 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.72[1.85; 4.00]148460 -NAOrnoy - BZDs, 1998 1 Tags Adjustment   - No  - No 2.72[1.85; 4.00]148460 -NAOrnoy - BZDs, 1998 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 2.72[1.85; 4.00]148460 -NAOrnoy - BZDs, 1998 1 All studiesAll studies 2.72[1.85; 4.00]148460 -NAOrnoy - BZDs, 1998 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.72[1.85; 4.00]148460 -NAOrnoy - BZDs, 1998 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Veroniki a (NMA) (Clobazam) (All indications) ...Veroniki a (NMA) (Clobazam) (All indications) (Combined fetal losses) 4.99[0.39; 48.13]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 Veroniki a (NMA) (Clonazepam) (All indication ...Veroniki a (NMA) (Clonazepam) (All indications) (Combined fetal losses) 2.74[0.41; 12.16]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 2.72[1.85; 4.00]NaN%460----Ornoy - BZDs, 1998 10.510.01.0