Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15330
R63129		 Ban - Diazepam (Other indications) (Controls unexposed, disease free), 2014 Chromosomal malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 0.49 [0.07;3.49] C
excluded (control group) 		1/1,159   619/351,785 620 1,159
ref
S15327
R63099		 Ban - Diazepam (Other indications) (Controls unexposed, sick), 2014 Chromosomal malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 0.52 [0.07;3.79] C 1/1,159   32/19,193 33 1,159
ref
Total 1 studies 0.52 [0.07;3.79] 33 1,159
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban - Diazepam (Other indications) (Controls unexposed, sick), 2014Ban - Diazepam, 2014 1 0.52[0.07; 3.79]331,1590%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: moderateROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Other indications) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 1 BZD Coexposure   - No (among psychiatric (ATD and/or p ...  - No (among psychiatric (ATD and/or psychotropics) medications) 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 1 All studiesAll studies 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15330

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.49[0.07; 3.49]6201,159 -NABan - Diazepam (Other indications) (Controls unexposed, disease free), 2014 1 unexposed, sick controlsunexposed, sick controls 0.52[0.07; 3.79]331,159 -NABan - Diazepam (Other indications) (Controls unexposed, sick), 2014 10.510.01.0