Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15440
R63510		 Kullander - Chlordiazepoxide, 1976 Minor malformations 1st trimester nested case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 0.55 [0.22;1.36] C 5/87   546/5,466 551 87
ref
Total 1 studies 0.55 [0.22;1.36] 551 87
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kullander - Chlordiazepoxide, 1976Kullander - Chlordiazepoxide, 1976 0.55[0.22; 1.36]551870%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.55[0.22; 1.36]55187 -NAKullander - Chlordiazepoxide, 1976 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.55[0.22; 1.36]55187 -NAKullander - Chlordiazepoxide, 1976 1 Tags Adjustment   - No  - No 0.55[0.22; 1.36]55187 -NAKullander - Chlordiazepoxide, 1976 1 BZD Coexposure   - Not specified  - Not specified 0.55[0.22; 1.36]55187 -NAKullander - Chlordiazepoxide, 1976 1 All studiesAll studies 0.55[0.22; 1.36]55187 -NAKullander - Chlordiazepoxide, 1976 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.55[0.22; 1.36]55187 -NAKullander - Chlordiazepoxide, 1976 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Veroniki a (NMA) (Clobazam) (All indications) ...Veroniki a (NMA) (Clobazam) (All indications) (Minor congenital malformations) Out of scale0.41[0.00; 35.92]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 Veroniki a (NMA) (Clonazepam) (All indication ...Veroniki a (NMA) (Clonazepam) (All indications) (Minor congenital malformations) 4.79[0.01; 605.80]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 0.55[0.22; 1.36]NaN%87----Kullander - Chlordiazepoxide, 1976 10.510.01.0