Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Language disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15584
R64115		 Coste - Clonazepam (Mixed indications), 2020 Health care utilization: Speech therapy - Mean age follow-up 4.4 years old during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: No (among antiseizure medications) 0.90 [0.70;1.10] 97/1,246   72,012/1,710,441 72,109 1,246
ref
Total 1 studies 0.90 [0.72;1.13] 72,109 1,246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste - Clonazepam (Mixed indications), 2020Coste - Clonazepam, 2020 1 0.90[0.70; 1.10]72,1091,2460%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: moderateROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.72; 1.13]72,1091,246 -NACoste - Clonazepam (Mixed indications), 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.72; 1.13]72,1091,246 -NACoste - Clonazepam (Mixed indications), 2020 1 Tags Adjustment   - Yes  - Yes 0.90[0.72; 1.13]72,1091,246 -NACoste - Clonazepam (Mixed indications), 2020 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 0.90[0.72; 1.13]72,1091,246 -NACoste - Clonazepam (Mixed indications), 2020 1 All studiesAll studies 0.90[0.72; 1.13]72,1091,246 -NACoste - Clonazepam (Mixed indications), 2020 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.72; 1.13]72,1091,246 -NACoste - Clonazepam (Mixed indications), 2020 10.510.01.0