Benzodiazepines (Psy and mixed indications) - Medication and Pregnancy KB

Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15459 R63563	Bjørk - Clonazepam (Mixed indications), 2022	Diagnosis of intellectual disability (ID): mild ID (F70), moderate ID (F71), severe ID (F72), and profound ID (F73) - Median follow up clonazepam 9.5 (5.5-13.9) years old	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: No (among antiseizure medications)	1.76 [1.06;2.92]	15/1,182 16,384/4,463,879	16,399	1,182		ref
					Total	1 studies	1.76 [1.06;2.92]		16,399	1,182
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded