Benzodiazepines (Psy and mixed indications) - Medication and Pregnancy KB

Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Severe cognitive developmental delay (Mental retardation) (3-6 years old)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15584 R64112	Coste - Clonazepam (Mixed indications), 2020	Diagnosis Mental retardation (F70–F79) - Mean age follow-up 4.4 years old	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: No (among antiseizure medications)	0.60 [0.20;1.90]	3/1,246 3,398/1,710,441	3,401	1,246		ref
					Total	1 studies	0.60 [0.19;1.85]		3,401	1,246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded