Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Neonatal hypotonia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15309
R62990		 Laegreid b - BZDs, 1992 Hypotonus - Clinical examination - At 18 months of age throughout pregnancy prospective cohort unexposed, disease free Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 5.77 [0.54;61.12] C 3/16   1/26 4 16
ref
Total 1 studies 5.77 [0.54;61.12] 4 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Laegreid b - BZDs, 1992Laegreid b - BZDs, 1992 5.77[0.54; 61.12]4160%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 1 Tags Adjustment   - No  - No 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 1 BZD Coexposure   - No (among psychiatric (ATD and/or p ...  - No (among psychiatric (ATD and/or psychotropics) medications) 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 1 All studiesAll studies 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.77[0.54; 61.12]416 -NALaegreid b - BZDs, 1992 10.510.01.0