Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Feeding difficulty

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15319
R63023		 Freeman - BZDs, 2018 Feeding difficulties during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 1.40 [0.65;3.04] 21/96   73/387 94 96
ref
Total 1 studies 1.40 [0.65;3.03] 94 96
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Freeman - BZDs, 2018Freeman - BZDs, 2018 1.40[0.65; 3.04]94960%ROB confusion: seriousROB selection: unclearROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 1 Tags Adjustment   - Yes  - Yes 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 1 All studiesAll studies 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.40[0.65; 3.03]9496 -NAFreeman - BZDs, 2018 10.510.01.0