Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Atresia or stenosis of other parts of small intestine

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15535
R63839		 Czeizel - Diazepam, 2003 Intestinal atresia/ stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched 1.10 [0.40;3.20] -/-   160/- - -
ref
S15363
R63204		 Safra - Diazepam, 1975 Small bowel atresia 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 1.02 [0.06;18.72] C 0/16   8/262 8 16
ref
Total 2 studies 1.09 [0.41;2.90] 8 16
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Czeizel - Diazepam, 2003Czeizel - Diazepam, 2003 1.10[0.40; 3.20]--89%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Safra - Diazepam, 1975Safra - Diazepam, 1975 1.02[0.06; 18.72]81611%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.09[0.41; 2.90]8160.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.09[0.41; 2.90]8160%NACzeizel - Diazepam, 2003 Safra - Diazepam, 1975 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.09[0.41; 2.90]8160%NACzeizel - Diazepam, 2003 Safra - Diazepam, 1975 2 Tags Adjustment   - No  - No 1.02[0.06; 18.72]816 -NASafra - Diazepam, 1975 1   - Yes  - Yes 1.10[0.39; 3.11]-- -NACzeizel - Diazepam, 2003 1 BZD Coexposure   - Not specified  - Not specified 1.02[0.06; 18.72]816 -NASafra - Diazepam, 1975 1   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.10[0.39; 3.11]-- -NACzeizel - Diazepam, 2003 1 MatchedMatched 1.10[0.39; 3.11]-- -NACzeizel - Diazepam, 2003 1 All studiesAll studies 1.09[0.41; 2.90]8160%NACzeizel - Diazepam, 2003 Safra - Diazepam, 1975 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.09[0.41; 2.90]159160%NACzeizel - Diazepam, 2003 Safra - Diazepam, 1975 20.510.01.0