Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Congenital glaucoma

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17691
R74676		 Cifuentes - Alprazolam, 2025 Congenital glaucoma 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 3.40 [0.21;54.80] C 0/93   351/222,904 351 93
ref
Total 1 studies 3.40 [0.21;54.80] 351 93
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cifuentes - Alprazolam, 2025Cifuentes - Alprazolam, 2025 3.40[0.21; 54.80]351930%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.40[0.21; 54.80]35193 -NACifuentes - Alprazolam, 2025 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.40[0.21; 54.80]35193 -NACifuentes - Alprazolam, 2025 1 Tags Adjustment   - No  - No 3.40[0.21; 54.80]35193 -NACifuentes - Alprazolam, 2025 1 BZD Coexposure   - Not specified  - Not specified 3.40[0.21; 54.80]35193 -NACifuentes - Alprazolam, 2025 1 All studiesAll studies 3.40[0.21; 54.80]35193 -NACifuentes - Alprazolam, 2025 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.40[0.21; 54.80]35193 -NACifuentes - Alprazolam, 2025 10.510.01.0