Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Syndactyly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17769
R75099		 Robert - BZDs, 1994 Syndactyly 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 3.08 [0.54;10.48] 3/-   -/- - -
ref
Total 1 studies 3.08 [0.70;13.57] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Robert - BZDs, 1994Robert - BZDs, 1994 3.08[0.54; 10.48]--0%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.08[0.70; 13.57]-- -NARobert - BZDs, 1994 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.08[0.70; 13.57]-- -NARobert - BZDs, 1994 1 Tags Adjustment   - No  - No 3.08[0.70; 13.57]-- -NARobert - BZDs, 1994 1 BZD Coexposure   - Not specified  - Not specified 3.08[0.70; 13.57]-- -NARobert - BZDs, 1994 1 All studiesAll studies 3.08[0.70; 13.57]-- -NARobert - BZDs, 1994 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.08[0.70; 13.57]-- -NARobert - BZDs, 1994 10.510.01.0