Benzodiazepines (Psy and mixed indications) - Medication and Pregnancy KB

Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Atrial septal defect

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15464 R63587	Blotière - Clonazepam (Other indications), 2019	Atrial septal defect	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	1.20 [0.10;4.20]	2/980 3,268/1,875,733	3,270	980		ref
S15593 R64185	Tinker - BZDs, 2019	Atrial septal defect [ASD] secundum or NOS	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.20 [0.70;1.80]	26/107 2,999/14,451	3,025	107		ref
S15335 R63157	Oberlander - BZDs, 2008	Atrial septal defects (ASD)	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications)	1.48 [0.21;10.65] ^C	1/968 75/107,320	76	968		ref
					Total	3 studies	1.21 [0.78;1.89]		6,371	2,055
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Other indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded