Benzodiazepines (Psy and mixed indications) updated on 02-10-2025

Postpartum hemorrhage

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17708
R74698
Jackson - BZDs, 2024 Post-partum hemorrhage (ICD-10 diagnosis code for PPH and a procedure code for blood transfusion) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed, disease free Adjustment: Yes BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) 3.51 [2.58;4.68] 59/542   3,072/106,564 3,131 542
ref
Total 1 studies 3.51 [2.61;4.73] 3,131 542
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Jackson - BZDs, 2024Jackson - BZDs, 2024 3.51[2.58; 4.68]3,1315420%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.51[2.61; 4.73]3,131542 -NAJackson - BZDs, 2024 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.51[2.61; 4.73]3,131542 -NAJackson - BZDs, 2024 1 Tags Adjustment   - Yes  - Yes 3.51[2.61; 4.73]3,131542 -NAJackson - BZDs, 2024 1 BZD Coexposure   - No (among psychiatric (ATD and/or p ...  - No (among psychiatric (ATD and/or psychotropics) medications) 3.51[2.61; 4.73]3,131542 -NAJackson - BZDs, 2024 1 All studiesAll studies 3.51[2.61; 4.73]3,131542 -NAJackson - BZDs, 2024 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.51[2.61; 4.73]3,131542 -NAJackson - BZDs, 2024 10.510.01.0