Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17647
R74529		 Berard (150 mg), 2019 Spontaneous abortion (6-20 weeks of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched 2.23 [1.96;2.54] 345/1,701   29,113/319,167 29,458 1,701
ref
S17651
R74562		 Inman (single 150mg dose), 1994 Spontaneous abortion (NOS) during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.45 [0.17;1.22] C 5/58   33/192 38 58
ref
Total 2 studies 1.09 [0.23;5.14] 29,496 1,759
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Berard (150 mg), 2019Berard, 2019 1 2.23[1.96; 2.54]29,4581,70155%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Inman (single 150mg dose), 1994Inman, 1994 2 0.45[0.17; 1.22]385845%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 90% 1.09[0.23; 5.14]29,4961,7590.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: 150 mg; 2: single 150mg dose;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.45[0.17; 1.22]3858 -NAInman (single 150mg dose), 1994 1 case control studiescase control studies 2.23[1.96; 2.54]29,4581,701 -NABerard (150 mg), 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.23[1.96; 2.54]29,4581,701 -NABerard (150 mg), 2019 1 unexposed, sickunexposed, sick 0.45[0.17; 1.22]3858 -NAInman (single 150mg dose), 1994 1 Tags Adjustment   - No  - No 0.45[0.17; 1.22]3858 -NAInman (single 150mg dose), 1994 1   - Yes  - Yes 2.23[1.96; 2.54]29,4581,701 -NABerard (150 mg), 2019 1 MatchedMatched 2.23[1.96; 2.54]29,4581,701 -NABerard (150 mg), 2019 1 All studiesAll studies 1.09[0.23; 5.14]29,4961,75990%NABerard (150 mg), 2019 Inman (single 150mg dose), 1994 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.23[1.96; 2.54]29,4581,701 -NABerard (150 mg), 2019 1 unexposed, sick controlsunexposed, sick controls Out of scale0.45[0.17; 1.22]3858 -NAInman (single 150mg dose), 1994 10.510.01.0