Methotrexate (Post-conception)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6775
R19127		 Weber-Schoendorfer (Controls exposed to other treatment, sick), 2014 Spontaneous abortion (fetus weighing <500 gm or <23 weeks of completed gestation) at least 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched 2.10 [1.30;3.20]
excluded (control group) 		39/188   44/459 83 188
ref
S10347
R37906		 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Spontaneous abortion (fetus weighing <500 gm or <23 weeks of completed gestation) at least 1st trimester prospective cohort unexposed, disease free Adjustment: Yes Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases Matched 2.50 [1.40;4.30] 39/188   79/1,107 118 188
ref
Total 1 studies 2.50 [1.43;4.38] 118 188
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Weber-Schoendorfer (Controls unexposed, disease free), 2014Weber-Schoendorfer, 2014 1 2.50[1.40; 4.30]1181880%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 Tags Adjustment   - Yes  - Yes 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 Indications   - Inflammatory diseases  - Inflammatory diseases 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 MatchedMatched 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 All studiesAll studies 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6775

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.50[1.43; 4.38]118188 -NAWeber-Schoendorfer (Controls unexposed, disease free), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.10[1.34; 3.29]83188 -NAWeber-Schoendorfer (Controls exposed to other treatment, sick), 2014 10.510.01.0