Methotrexate (Post-conception)

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10694
R39502		 Cooper (Controls exposed to other treatment, sick), 2014 Cardiac defects 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 3.40 [0.38;30.37] C
excluded (control group) 		1/23   5/379 6 23
ref
S8721
R29479		 Cooper (Controls unexposed, sick), 2014 Cardiac defects 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Inflammatory diseases 23.79 [0.94;602.59] C 1/23   0/171 1 23
ref
S6761
R29963		 Dawson, 2014 Congenital heart defects (CHD) 1st trimester case control unexposed (general population or NOS) Adjustment: No Exposed group: MTX (polytherapy or not specified) Indications: Any or not specified 2.29 [0.45;11.83] C 5/7   11,017/21,128 11,022 7
ref
Total 2 studies 4.80 [0.57;40.39] 11,023 30
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cooper (Controls unexposed, sick), 2014Cooper, 2014 1 23.79[0.94; 602.59]12332%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Dawson, 2014Dawson, 2014 2.29[0.45; 11.83]11,022768%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 37% 4.80[0.57; 40.39]11,023300.950.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 23.79[0.94; 602.59]123 -NACooper (Controls unexposed, sick), 2014 1 case control studiescase control studies 2.29[0.45; 11.83]11,0227 -NADawson, 2014 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.29[0.45; 11.83]11,0227 -NADawson, 2014 1 unexposed, sickunexposed, sick 23.79[0.94; 602.59]123 -NACooper (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 4.80[0.57; 40.39]11,0233037%NACooper (Controls unexposed, sick), 2014 Dawson, 2014 2 Exposed group   - MTX (polytherapy or not specified)  - MTX (polytherapy or not specified) 4.80[0.57; 40.39]11,0233037%NACooper (Controls unexposed, sick), 2014 Dawson, 2014 2 Indications   - Any or not specified  - Any or not specified 2.29[0.45; 11.83]11,0227 -NADawson, 2014 1   - Inflammatory diseases  - Inflammatory diseases 23.79[0.94; 602.59]123 -NACooper (Controls unexposed, sick), 2014 1 All studiesAll studies 4.80[0.57; 40.39]11,0233037%NACooper (Controls unexposed, sick), 2014 Dawson, 2014 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 10694

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.29[0.45; 11.83]11,0227 -NADawson, 2014 1 unexposed, sick controlsunexposed, sick controls Out of scale23.79[0.94; 602.59]123 -NACooper (Controls unexposed, sick), 2014 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.40[0.38; 30.37]623 -NACooper (Controls exposed to other treatment, sick), 2014 10.510.01.0