Sumatriptan

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.00 [0.87, 1.14]0%5 studies57,0074,840not evaluable ROB-
Major congenital malformations1.07 [0.39, 2.88]25%4 studies1222,583not evaluable ROB-
Congenital heart defects2.31 [0.84, 6.39]-1 study87362not evaluable ROB-
Digestive system anomalies0.69 [0.04, 11.18]-1 study36258not evaluable ROB-
Genital anomalies0.80 [0.05, 12.89]-1 study31458not evaluable ROB-
Limb defects1.36 [0.08, 22.06]-1 study18458not evaluable ROB-
Minor congenital malformations0.12 [0.01, 2.29]-1 study467not evaluable ROB-
Nervous system anomalies1.20 [0.07, 19.50]-1 study20858not evaluable ROB-
Oro-facial clefts0.85 [0.05, 13.77]-1 study29458not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.60 [0.43, 5.97]79%3 studies103691not evaluable ROB-
Low birth weight (< 2500g)0.92 [0.64, 1.33]0%3 studies801,267not evaluable ROB-
Small for gestational age (weight)0.88 [0.56, 1.40]-1 study82575not evaluable ROB-
Very low birth weight (< 1500g)0.73 [0.10, 5.40]-1 study658not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean1.53 [0.74, 3.16]-1 study3880not evaluable ROB-
Postpartum hemorrhage0.49 [0.25, 0.96]-1 study82104not evaluable ROB3.51 [.; 1.25]

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neonatal medical care0.39 [0.15, 1.01]-1 study47104not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)1.06 [0.68, 1.67]26%4 studies7354,196not evaluable ROB-
Elective/induced termination of pregnancy1.02 [0.50, 2.05]0%3 studies1624,198not evaluable ROB-
Late intrauterine deaths (> 22 weeks)0.91 [0.16, 5.06]0%3 studies204,198not evaluable ROB-
Ectopic pregnancy1.21 [0.07, 19.73]-1 study276not evaluable ROB-
Perinatal death1.23 [0.40, 3.80]-1 study658not evaluable ROB-

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