metaPreg - Leflunomide during pregnancy

Leflunomide

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	0.97 [0.81, 1.16]	0%	3 studies	14,378	116	not evaluable	ROB	-
Major congenital malformations	0.97 [0.81, 1.16]	0%	3 studies	14,378	116	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	0.62 [0.21, 1.84]	-	1 study	18	56	not evaluable	ROB	-
Minor congenital malformations	1.87 [0.92, 3.79]	-	1 study	53	51	not evaluable	ROB	-
Congenital heart defects	3.11 [0.99, 9.77]	-	1 study			not evaluable	ROB	-
Limb defects	1.38 [0.96, 1.98]	-	1 study			not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	2.04 [1.07, 3.90]	0%	2 studies	10,868	77	not evaluable	ROB	3.50 [1.33; .]
Low birth weight (< 2500g)	1.06 [0.90, 1.25]	0%	2 studies	2	3	not evaluable	ROB	-
Small for gestational age (length)	0.40 [0.08, 1.97]	-	1 study	10	56	not evaluable	ROB	-
Small for gestational age (weight)	2.08 [0.75, 5.75]	-	1 study	17	56	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	-	-	0 study					-
Gestational diabetes	2.63 [0.43, 16.26]	-	1 study	5	56	not evaluable	ROB	-
Preeclampsia	3.68 [0.88, 15.35]	-	1 study	9	56	not evaluable	ROB	-
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Child/Infant head circumference abnormalities (> 1 year)	0.94 [0.30, 2.95]	-	1 study	14	56	not evaluable	ROB	-
Child/Infant lenght abnormalities (> 1 year)	2.57 [0.78, 8.53]	-	1 study	12	56	not evaluable	ROB	-
Child/Infant weight abnormalities (> 1 year)	1.05 [0.41, 2.72]	-	1 study	21	56	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.09 [0.90, 1.32]	0%	2 studies	17,747	112	not evaluable	ROB	-
Elective/induced termination of pregnancy	0.84 [0.07, 9.44]	-	1 study	3	63	not evaluable	ROB	-
Late intrauterine deaths (> 22 weeks)	0.56 [0.02, 13.89]	-	1 study	1	63	not evaluable	ROB	-
Intrauterine deaths (as a whole or unspecified)	1.13 [0.08, 16.31]	-	1 study	5	3	not evaluable	ROB	-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
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