Misoprostol

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Major congenital malformations2.86 [1.44, 5.65]0%3 studies36388not evaluable ROB5.16 [2.24; .]
All congenital malformations (majors, minors, majors and minors, or unspecified)2.64 [1.03, 6.76]-1 study86118not evaluable ROB4.72 [1.21; .]
Limb defects1.90 [0.26, 13.97]-1 study3472not evaluable ROB-
Nervous system anomalies4.23 [1.47, 12.16]-1 study34145not evaluable ROB7.93 [2.30; .]
Urinary malformations1.60 [0.38, 6.74]-1 study34176not evaluable ROB-
Ear, face and neck anomalies0.74 [0.18, 3.06]-1 study34365not evaluable ROB-
Limb reduction defects (LRD)15.12 [5.53, 41.34]0%2 studies6147not evaluable ROB29.74 [10.54; .]
Moebius syndrome32.19 [10.54, 98.31]0%2 studies12574not evaluable ROB63.88 [20.57; .]
Oro-facial clefts5.74 [1.34, 24.59]-1 study3452not evaluable ROB10.96 [2.01; .]
Abdominal wall defects6.36 [2.38, 16.96]-1 study3423not evaluable ROB12.20 [4.20; .]
Club foot / Talipes equinovarus1.02 [0.24, 4.31]-1 study34270not evaluable ROB-
Congenital heart defects3.67 [0.49, 27.50]-1 study3439not evaluable ROB-
Vascular disruption anomalie22.00 [6.59, 73.42]-1 study9344not evaluable ROB43.49 [12.66; .]

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)3.51 [1.38, 8.91]-1 study20145not evaluable ROB6.48 [2.11; .]

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)2.16 [1.40, 3.34]36%2 studies36296not evaluable ROB3.74 [2.14; .]
Intrauterine deaths (as a whole or unspecified)2.27 [1.30, 3.97]-1 study4694not evaluable ROB3.97 [1.92; .]
Elective/induced termination of pregnancy5.33 [2.93, 9.71]-1 study74236not evaluable ROB10.14 [5.31; .]
Late intrauterine deaths (> 22 weeks)7.66 [0.39, 149.14]-1 study3236not evaluable ROB-
Therapeutic terminations of pregnancy2.18 [0.40, 12.02]-1 study6236not evaluable ROB-

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