Methotrexate (Post-conception)

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)3.16 [1.52, 6.54]0%5 studies32,664143not evaluable ROB5.76 [2.42; .]
Major congenital malformations2.70 [1.21, 6.02]0%4 studies32,664143not evaluable ROB4.85 [1.72; .]
Congenital heart defects4.80 [0.57, 40.39]37%2 studies11,02330not evaluable ROB-
Digestive system anomalies2.51 [0.10, 63.53]-1 study123not evaluable ROB-
Genital anomalies7.58 [0.15, 391.43]-1 study23not evaluable ROB-
Limb defects7.58 [0.15, 391.43]-1 study23not evaluable ROB-
Minor congenital malformations0.83 [0.19, 3.57]-1 study25104not evaluable ROB-
Nervous system anomalies7.58 [0.15, 391.43]-1 study23not evaluable ROB-
Urinary malformations1.50 [0.07, 32.20]-1 study223not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)0.70 [0.20, 2.53]-1 study3521not evaluable ROB-
Small for gestational age (weight)1.73 [0.35, 8.53]-1 studynot evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neonatal disorders (as a whole)1.14 [0.13, 9.77]-1 study821not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Late intrauterine deaths (> 22 weeks)5.05 [1.21, 21.03]0%2 studies9211not evaluable ROB9.58 [1.73; .]
Early intrauterine death (< 22 weeks)2.50 [1.43, 4.38]-1 study118188not evaluable ROB4.44 [2.21; .]
Elective/induced termination of pregnancy7.40 [4.49, 12.18]-1 study98188not evaluable ROB14.28 [8.46; .]
Therapeutic terminations of pregnancy4.23 [1.78, 10.04]-1 study22188not evaluable ROB7.93 [2.96; .]

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value

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