id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S10176 R37259 |
Blotière (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 | Cleft lip with or without cleft palate | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No |
1.17 [0.06;24.43] C excluded (control group) |
0/512 2/2,997 | 2 | 512 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9766 R34909 |
Blotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 | Cleft lip with or without cleft palate | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: No | 1.12 [0.07;17.92] C | 0/512 1,637/1,875,733 | 1,637 | 512 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S10291 R37677 |
Vajda (Carbamazepine) (Controls unexposed, sick), 2013 | Palate/lip malformation | at least 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 0.41 [0.01;20.58] C | 0/361 0/147 | 0 | 361 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9664 R34409 |
Jentink (Carbamazepine), 2010 | Cleft lip (with or without palate) | 1st trimester | case control | unexposed (general population or NOS) | Adjustment: Yes | no data | 1/- -/- | - | - |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9648 R34335 |
Viinikainen (Carbamazepine) (Controls unexposed, sick) a, 2006 | Cleft lip | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 2.19 [0.09;54.89] C | 1/72 0/52 | 1 | 72 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9652 R34349 |
Artama (Carbamazepine), 2005 | Cleft lip/ cleft palate | 1st trimester | retrospective cohort (registry) | unexposed, sick | Adjustment: No | 0.23 [0.01;4.86] C | 0/805 2/939 | 2 | 805 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 5 studies | 0.73 [0.15;3.55] | 1,640 | 1,750 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Carbamazepine) (Controls unexposed NOS) (Mixed indications; 2: Carbamazepine) (Controls unexposed, sick; 3: Carbamazepine; 4: Carbamazepine) (Controls unexposed, sick) ; 5: Carbamazepine;
Asymetry test p-value = 0.9350 (by Egger's regression)
slope=-0.2298 (1.0926); intercept=-0.0536 (0.6054); t=0.0885; p=0.9350
excluded 10176