id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9602 R34036 |
Aydin (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2020 | Preeclampsia/ eclampsia | throughout pregnancy | retrospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.45 [0.01;25.16] C excluded (control group) |
0/15 0/7 | 0 | 15 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9603 R34046 |
Aydin (Carbamazepine) (Controls unexposed, sick), 2020 | Preeclampsia/ eclampsia | throughout pregnancy | retrospective cohort | unexposed, sick | Adjustment: No | 1.48 [0.03;79.05] C | 0/15 0/22 | 0 | 15 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9761 R34850 |
Cohen (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 | Preeclampsia | early pregnancy | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: Yes |
0.96 [0.61;1.52] excluded (control group) |
78/1,232 129/2,682 | 207 | 1,232 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9762 R34857 |
Cohen (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 | Preeclampsia | early pregnancy | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes | 1.29 [0.94;1.77] | 78/1,232 53,634/1,440,631 | 53,712 | 1,232 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9640 R34294 |
Pennell (Carbamazepine), 2012 | Gestational hypertension | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: No | 1.06 [0.30;3.78] C | 5/92 5/97 | 10 | 92 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9752 R34821 |
Borthen (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2011 | Pre-eclampsia | during pregnancy (anytime or not specified) | retrospective cohort | exposed to other treatment, sick excluded | Adjustment: No |
0.31 [0.06;1.67] C excluded (control group) |
2/28 6/30 | 8 | 28 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9754 R34829 |
Borthen (Carbamazepine) (Controls unexposed, disease free), 2011 | Pre-eclampsia | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, disease free excluded | Adjustment: No Matched |
1.40 [0.30;6.50] excluded (control group) |
2/28 11/205 | 13 | 28 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9756 R34837 |
Borthen (Carbamazepine) (Controls unexposed, sick), 2011 | Pre-eclampsia | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 0.55 [0.11;2.62] C | 2/28 11/89 | 13 | 28 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 4 studies | 1.24 [0.92;1.67] | 53,735 | 1,367 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Carbamazepine) (Controls unexposed, sick; 2: Carbamazepine) (Controls unexposed NOS) (Mixed indications; 3: Carbamazepine; 4: Carbamazepine) (Controls unexposed, sick;
Asymetry test p-value = NaN (by Egger's regression)
not enought points
excluded 9752, 9754, 9761, 9602