id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S9364 R32753 |
Tomson (Valproate), 2015 | Perinatal death (during the first week after delivery from gestational week 24) | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 3.82 [0.98;14.79] C | 7/1,083 3/1,763 | 10 | 1,083 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9283 R32208 |
Artama (Valproate) (Controls exposed to Lamotrigine, sick), 2013 | Perinatal death (stillbirth or early neonatal death (0–6 days of age)) | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
3.70 [0.21;65.18] C excluded (control group) |
7/706 0/173 | 7 | 706 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9284 R32220 |
Artama (Valproate) (Controls unexposed, disease free), 2013 | Perinatal death (stillbirth or early neonatal death (0–6 days of age)) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, disease free excluded | Adjustment: Yes |
1.49 [0.70;3.18] excluded (control group) |
7/706 3,543/721,948 | 3,550 | 706 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9285 R32232 |
Artama (Valproate) (Controls unexposed, sick), 2013 | Perinatal death (stillbirth or early neonatal death (0–6 days of age)) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.68 [0.58;4.84] | 7/706 10/1,800 | 17 | 706 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S9335 R32577 |
Canger (Valproate), 1999 | Perinatal deaths (NOS) | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 0.56 [0.01;29.28] C | 0/44 0/25 | 0 | 44 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 2.16 [0.95;4.89] | 27 | 1,833 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Valproate; 2: Valproate) (Controls unexposed, sick; 3: Valproate;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 9283, 9284