id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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S15868 R65363 |
Dreier (Carbamazepine) (Epilepsy) (Controls exposed to LTG), 2023 | Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | exposed to other treatment, sick excluded | Adjustment: No |
2.12 [1.32;3.39] C excluded (control group) |
36/2,665 34/5,288 | 70 | 2,665 |
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S15869 R65379 |
Dreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 | Intellectual disability - Corresponding ICD-10 F-chapter - Up to 22 years of age | during pregnancy (anytime or not specified) | population based cohort propective | unexposed, sick | Adjustment: Yes | 1.11 [0.73;1.70] | 36/2,665 184/22,203 | 220 | 2,665 |
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S12896 R53292 |
Adams (Carbamazepine), 2022 | Full Scale IQ - The Wechsler Intelligence Scale for Children, 3rd Edition (WISC-III) (mean >6 years old) | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No extrapolated (cont. endpoint) Matched | 2.98 [1.33;6.66] | -/41 -/41 | - | 41 |
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S15377 R63353 |
Thomas (Carbamazepine), 2022 | Full-scale IQ - Wechsler Intelligence Scale for Children or Adult - Ages 13 to 21 years (mean of 16.5 ± 2.2 years) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No extrapolated (cont. endpoint) | 1.85 [0.55;6.31] | -/38 -/11 | - | 38 |
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S8324 R53293 |
Baker (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2015 | Mean child Full scale IQ - Differential ability scales (DAS) (age mean >6 years old) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick excluded | Adjustment: No extrapolated (cont. endpoint) |
0.77 [0.34;1.77] excluded (control group) |
-/50 -/29 | - | 50 |
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S8254 R53294 |
Baker (Carbamazepine) (Controls unexposed, disease free), 2015 | IQ <85 - Differential ability scales (DAS) (age mean >6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: Yes |
3.50 [1.10;10.20] excluded (control group) |
-/50 -/210 | - | 50 |
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S8326 R53295 |
Baker (Carbamazepine) (Controls unexposed, sick), 2015 | Mean child Full scale IQ - Differential ability scales (DAS) (age mean >6 years old) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No extrapolated (cont. endpoint) | 0.88 [0.37;2.11] | -/50 -/25 | - | 50 |
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S386 R53299 |
Meador (Carbamazepine), 2013 | IQ <85 (DAS) (at 6 years old) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: Yes | 3.21 [0.60;17.19] C | 5/61 2/74 | 7 | 61 |
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S6188 R53300 |
Nadebaum (Carbamazepine), 2011 | Full-scale child's IQ (Wechsler Intelligence Scale for Children (WISC)) | during pregnancy (anytime or not specified) | prospective cohort | exposed to other treatment, sick | Adjustment: No extrapolated (cont. endpoint) | 1.82 [0.48;6.95] | -/34 -/9 | - | 34 |
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S6106 R53305 |
Titze (Carbamazepine) (Controls unexposed, disease free), 2008 | Learning disability (IQ<70) (German versions of the revised Wechsler Intelligence Scales for children and for adults) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, disease free excluded | Adjustment: No Matched |
13.86 [0.24;809.27] C excluded (control group) |
0/4 0/49 | 0 | 4 |
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S6112 R53306 |
Titze (Carbamazepine) (Controls unexposed, sick), 2008 | Learning disability (IQ<70) (German versions of the revised Wechsler Intelligence Scales for children and for adults) | during pregnancy (anytime or not specified) | prospective cohort | unexposed, sick | Adjustment: No | 1.10 [0.04;33.38] C | 0/4 1/13 | 1 | 4 |
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S5831 R53301 |
Viinikainen (Carbamazepine) b, 2006 | Full Scale IQ (FIQ) < 1SD Wechsler Intelligence Scale for Children (WISC III) | throughout pregnancy | prospective cohort | unexposed, sick | Adjustment: No | 5.95 [0.26;138.26] C | 2/13 0/13 | 2 | 13 |
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S5560 R53307 |
Vinten (Carbamazepine), 2005 | IQ score <69 Wechsler Intelligence Scale for Children (WISC III) (Aged between 6 and 16 years) | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No | 1.03 [0.28;3.83] C | 4/52 6/80 | 10 | 52 |
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S5541 R53291 |
Adab (Carbamazepine), 2004 | Mean Full Scale IQ Wechsler Intelligence Scale for Children (WISC) (Aged between 6 and 16 years) | during pregnancy (anytime or not specified) | retrospective cohort | unexposed, sick | Adjustment: No extrapolated (cont. endpoint) | 0.85 [0.45;1.60] | -/52 -/80 | - | 52 |
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S7236 R53296 |
Gaily (Carbamazepine) (Controls unexposed, disease free), 2004 | Full scale IQ (Wechsler Preschool and Primary Scale of Intelligence Revised (WPPSI-R) or Wechsler Intelligence Scale for Children Revised (WISC-R)) | 2nd and/or 3rd trimester | prospective cohort | unexposed, disease free excluded | Adjustment: No extrapolated (cont. endpoint) |
0.80 [0.49;1.30] excluded (control group) |
-/86 -/140 | - | 86 |
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S5557 R53297 |
Gaily (Carbamazepine) (Controls unexposed, sick), 2004 | Full scale IQ (Wechsler Preschool and Primary Scale of Intelligence Revised (WPPSI-R) or Wechsler Intelligence Scale for Children Revised (WISC-R)) | 2nd and/or 3rd trimester | prospective cohort | unexposed, sick | Adjustment: No extrapolated (cont. endpoint) | 0.65 [0.34;1.26] | -/86 -/45 | - | 86 |
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ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 11 studies | 1.19 [0.86;1.65] | 240 | 3,096 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Carbamazepine) (Epilepsy) (Controls unexposed, sick; 2: Carbamazepine; 3: Carbamazepine; 4: Carbamazepine) (Controls unexposed, sick; 5: Carbamazepine; 6: Carbamazepine; 7: Carbamazepine) (Controls unexposed, sick; 8: Carbamazepine) ; 9: Carbamazepine; 10: Carbamazepine; 11: Carbamazepine) (Controls unexposed, sick;
Asymetry test p-value = 0.1863 (by Egger's regression)
slope=-0.2216 (0.2841); intercept=0.9497 (0.6637); t=1.4309; p=0.1863
excluded 7236, 6106, 8324, 8254, 15868