id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S333 R17484 |
Tomson (Carbamazepine), 2015 | Perinatal death (during the first week after delivery from gestational week 24) | at least 1st trimester | prospective cohort | exposed to other treatment, sick | Adjustment: No | 0.37 [0.04;3.60] C | 1/1,570 3/1,763 | 4 | 1,570 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S5925 R15070 |
Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013 | Perinatal death (stillbirth or early neonatal death (0–6 days of age)) | during pregnancy (anytime or not specified) | population based cohort retrospective | exposed to other treatment, sick excluded | Adjustment: No |
3.37 [0.20;57.85] C excluded (control group) |
10/1,084 0/173 | 10 | 1,084 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S5909 R14885 |
Artama (Carbamazepine) (Controls unexposed, disease free), 2013 | Perinatal death (stillbirth or early neonatal death (0–6 days of age)) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, disease free excluded | Adjustment: Yes |
1.92 [1.02;3.60] excluded (control group) |
10/1,084 3,543/721,948 | 3,553 | 1,084 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S5917 R14981 |
Artama (Carbamazepine) (Controls unexposed, sick), 2013 | Perinatal death (stillbirth or early neonatal death (0–6 days of age)) | during pregnancy (anytime or not specified) | population based cohort retrospective | unexposed, sick | Adjustment: Yes | 1.82 [0.72;4.59] | 10/1,084 10/1,800 | 20 | 1,084 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
S6509 R20083 |
Canger (Carbamazepine), 1999 | Perinatal deaths (NOS) | 1st trimester | prospective cohort | unexposed, sick | Adjustment: No | 1.11 [0.05;23.83] C | 2/113 0/25 | 2 | 113 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Total | 3 studies | 1.42 [0.62;3.25] | 26 | 2,767 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives |
1: Carbamazepine; 2: Carbamazepine) (Controls unexposed, sick; 3: Carbamazepine;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 5925, 5909